Pregrado

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12672/27371

Browse

Recent Submissions

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Datasheet: Association of the rs1042522 SNP with prostate cancer risk: a study of cancer tissues, primary tumor cultures, and serum samples from a Spanish Caucasian population.xlsx
    (Frontiers, 2024-08-13) Toscano Guerra, Emily Marisol; Maggio, Valentina; García, Javier; Semidey, Maria Eugenia; Celma, Ana; Morote, Juan; De Torres, Inés; Giralt, Marina; Ferrer-Costa, Roser; Paciucci, Rosanna
    assessment strategies. The TP53 gene, a tumor suppressor gene frequently mutated in cancer, commonly harbors the rs1042522 single nucleotide polymorphism (SNP), known as the P72R SNP, which may influence PCa susceptibility. This study investigated the prevalence of the P72R SNP in European Caucasian PCa samples and its association with PCa risk.MethodsGenotyping was conducted on 12 hormone-naïve aggressive PCa cultures (hnPCs) from untreated patients (Gleason ≥8), 11 radical prostatectomies (RP), and 94 serum samples using DNA Sanger sequencing and melting curve analysis. Comparative analysis utilized data from the GnomAD database’s European Caucasian non-cancer population.ResultsOur results demonstrate a significantly higher frequency of the P72R SNP in PCa samples and serums compared to the general European non-cancer population. A robust and statistically significant association (p < 0.0001) between the SNP and prostate cancer risk was identified, with an odds ratio of 7.937 (95% CI 5.37-11.00). Notably, the G allele (R72) showed a pronounced prevalence in high Gleason score (≥8) patients, although statistical significance was not reached. These results highlight a potential association with undifferentiated and malignant PCa lesions.ConclusionThe compelling association between the P72R SNP and prostate cancer risk underscores the potential utility of this marker for the early identification of patients at risk of aggressive metastatic prostate cancer. This insight could empower further research to intervene at an early stage by offering enhanced opportunities for timely and targeted interventions.
  • No Thumbnail Available
    Item
    Planktic foraminiferal I/Ca, Fe/Ca, Al/Ca and Mg/Ca ratios in core top samples from cleaning experiments and iodine stabalization experiments
    (PANGAEA, 2021-06-17) Winkelbauer, Helge Arne; Córdova Rodríguez, Kathy Zindzi Liyi; Reyes-Macaya, Dharma; Scott, Jennifer; Glock, Nicolaas; Lu, Zunli; Hamilton, Elliott; Chenery, Simon; Holdship, Philip; Charlotte, Dormon; Hoogakker, Babette A A
    Planktic and benthic foraminifera iodine (I) to calcium (Ca) molar ratios have been proposed as an exciting new proxy to assess subsurface and bottom water oxygenation in the past. Compared to trace metals, the analysis of iodine in foraminifera calcite is more challenging, as iodine is volatile in acid solution. Here we compare previous analyses that use tertiary amine with alternative analyses using tetramethylammonium hydroxide (TMAH) and ammonium hydroxide (NH4OH). In addition, we assess the effect of sample size and cleaning on planktic and benthic foraminiferal I/Ca. Our stabilization experiments with TMAH and NH4OH show similar trends as those using tertiary amine, giving relatively low I/Ca ratios for planktic and benthic foraminifera samples from locations with either poorly oxygenated subsurface waters or bottom waters, and high ratios for locations characterized by well oxygenated subsurface or bottom waters. This suggests that both alternative methods are suitable to stabilize iodine initially dissolved in acid. In terms of number of planktic foraminifera analyzed, our results show a wide spread in I/Ca when samples contain 5 to 10 specimens. Samples containing 20 specimens or more show I/Ca values centered around the average of the smaller samples, indicated that the larger sample sizes are more representative of the average planktic foraminifera sample community. The impact of cleaning on planktic and benthic foraminifera I/Ca ratios is very similar to Mg/Ca, with the largest effect occurring during the clay removal step. Largest iodine contaminations were recorded at locations characterized by moderate to high organic carbon contents. We recommend doubling the oxidative cleaning step (4 instead of 2 steps) to ensure that all organic material is removed.
  • No Thumbnail Available
    Item
    Data for: REBEn 2022-0768: Percepciones, maltrato y religión como predictores del impacto psicoemocional en enfermeros durante la pandemia COVID-19
    (Revista Brasileira de Enfermagem, 2023) Zeladita-Huaman, Jhon Alex; De la Cruz-Espinoza, Stefanny Lizbeth; Samillán-Yncio, Gabriela; Castro-Murillo, Rosa; Franco Chalco, Eduardo; Zegarra-Chapoñán, Roberto
    En este repositorio se encuentra la base de datos del estudio titulado: “Percepciones, maltrato y religión como predictores del impacto psicoemocional en enfermeros durante la pandemia COVID-19”, publicado en el Revista Brasileira de Enfermagem. Contiene información vinculada a las variables de ansiedad, estrés y depresión recopilada en profesionales de enfermería de establecimientos de atención primaria y atención especializada. (2022-12-13)